1-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪合成路线

参考文献

Myriad Pharmaceuticals, Inc.
Patent: US2004/14763 A1, 2004 ;
Location in patent: Page 21 ;

84358-13-41-Boc-4-哌啶甲酸

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

SCHERING CORPORATION
Patent: WO2007/70398 A1, 2007 ;
Location in patent: Page/Page column 255 ;
WO 2007/070398 A1

6638-79-5二甲羟胺盐酸盐

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Bristol-Myers Squibb Company
Patent: US2007/259850 A1, 2007 ;
Location in patent: Page/Page column 76-77 ;
US 20070259850 A1

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Aventis Pharmaceuticals Inc.; Aventis Pharma Deutschland GmbH
Patent: US2005/261341 A1, 2005 ;

478408-77-4+

6638-79-5二甲羟胺盐酸盐+

84358-13-41-Boc-4-哌啶甲酸+

530-62-1N,N'-羰基二咪唑

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Daugs, Edward D.; Evans, Jonathan C.; Flemming, Hans-Wolfram; Hilpert, Thomas Heinz Eduard; Koek, Johannes Nicolaas; Laskovics, Frederick M.; Stolz-Dunn, Sandra K.; Tomlinson, Ian A.
Patent: US2002/151717 A1, 2002 ;

84358-13-41-Boc-4-哌啶甲酸+

1117-97-1N-甲基-N-甲氧基胺盐酸盐

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 191 ;

142851-03-4N-Boc-4-哌啶甲酸乙酯+

1117-97-1N-甲基-N-甲氧基胺盐酸盐

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Wei; Brown; Takasaki; Plobeck; Delorme; Zhou; Yang; Jones; Gawell; Gagnon; Schmidt; Yue; Walpole; Payza; St-Onge; Labarre; Godbout; Jakob; Butterworth; Kamassah; Morin; Projean; Ducharme; Roberts
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3895 - 3905

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Daugs, Edward D.; Evans, Jonathan C.; Flemming, Hans-Wolfram; Hilpert, Thomas Heinz Eduard; Koek, Johannes Nicolaas; Laskovics, Frederick M.; Stolz-Dunn, Sandra K.; Tomlinson, Ian A.
Patent: US2002/151717 A1, 2002 ;

6638-79-5二甲羟胺盐酸盐+

84358-13-41-Boc-4-哌啶甲酸+

530-62-1N,N'-羰基二咪唑

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Aventis Pharmaceuticals Inc.; Aventis Pharma Deutschland GmbH
Patent: US2005/261341 A1, 2005 ;

124443-68-1N-Boc-4-哌啶甲酸甲酯+

1117-97-1N-甲基-N-甲氧基胺盐酸盐

139290-70-31-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪

参考文献

Golebiowski, Adam; Whitehouse, Darren; Beckett, R. Paul; Van Zandt, Michael; Ji, Min Koo; Ryder, Todd R.; Jagdmann, Erik; Andreoli, Monica; Lee, Yung; Sheeler, Ryan; Conway, Bruce; Olczak, Jacek; Mazur, Marzena; Czestkowski, Wojciech; Piotrowska, Wieslawa; Cousido-Siah, Alexandra; Ruiz, Francesc X.; Mitschler, Andre; Podjarny, Alberto; Schroeter, Hagen
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4837 - 4841