1-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪合成路线 （共 34 条）
反应条件
1: aq. NaOH / dioxane / 20 °C 2: PyBOP; Et3N / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 15 p. 4013 - 4017
反应条件
1: 7.67 g / Na2CO3 / tetrahydrofuran; H2O / 1 h / Heating 2: 98 percent / iPrMgCl / tetrahydrofuran / 1 h / -5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3895 - 3905
反应条件
sodium hydroxide in water; toluene T=20°C; Product distribution / selectivity;
参考文献
EP1734037 A2, ;
Page/Page column 58 ;
反应条件
1: 7.67 g / Na2CO3 / tetrahydrofuran; H2O / 1 h / Heating 2: 98 percent / iPrMgCl / tetrahydrofuran / 1 h / -5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3895 - 3905
反应条件
in dichloromethane; 1,1'-carbonyldiimidazole
反应条件
in dichloromethane T=20 - 28°C; 2.33 - 72 h; Product distribution / selectivity;
参考文献
EP1734037 A2, ;
Page/Page column 55-58 ;
反应条件
in tetrahydrofuran T=-20 - 20°C; Acylation; 72 h;
参考文献
Cain, Gary A.; Teleha, Christopher A.
Organic Preparations and Procedures International, 2000 , vol. 32, # 1 p. 96 - 99
反应条件
1.1: lithium hydroxide hydrate / tetrahydrofuran; water / 15 h / 0 - 25 °C 2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 0 - 25 °C / |Inert atmosphere 2.2: 0.5 h / 25 °C 2.3: 15 h / 25 °C View Scheme
反应条件
isopropylmagnesium chloride
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 8 p. 2989 - 3002
