[3-[(2,6-二甲基苯基)氨基甲酰]-1,2-恶唑-5-基]甲基苯甲酸酯合成路线 （共 6 条）
反应条件
triethylamine in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: conc. H2SO4 / acetic acid 2: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 3: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 4: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 95 percent / 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 5: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 5: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 2: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 3: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 2: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
