甲基5-(羟基甲基)-1,2-恶唑-3-羧酸酯合成路线 （共 7 条）
反应条件
Amberlite H-15 in methanol T=50°C; Hydrolysis; 5 h;
参考文献
Simoni, Daniele; Invidiata, Francesco Paolo; Rondanin, Riccardo; Grimaudo, Stefania; Cannizzo, Giuliana; Barbusca, Eleonora; Porretto, Ferdinando; D'Alessandro, Nicola; Tolomeo, Manlio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 4961 - 4969
反应条件
potassium carbonate in chloroform Ambient temperature;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 95 percent / 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 5: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 95 percent / 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
sodium hydroxide in ethanol Ambient temperature;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 95 percent / 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 95 percent / 10percent aq. NaOH / ethanol / Ambient temperature 2: conc. H2SO4 / acetic acid 3: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 4: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 5: 40 percent / diethylaminosulfur trifluoride (DAST) / CH2Cl2 / 1 h / -65 - 20 °C View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
