5-羟基甲基异噁唑-3-羧酸合成路线 （共 9 条）
反应条件
1: With water; sodium hydroxide T=20°C; 3.5 h; 2: With hydrogenchloride in water pH=2;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 147 ;
WO 2010/142801 A1
反应条件
sodium hydroxide in ethanol Ambient temperature;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: conc. H2SO4 / acetic acid 2: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 3: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 4: 75 percent / Et3N / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: conc. H2SO4 / acetic acid 2: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: conc. H2SO4 / acetic acid 2: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 3: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: conc. H2SO4 / acetic acid 2: 1.) POCl3, 2.) Et3N / 1.) THF, 0 deg C, 2.) THF, RT, 12 h 3: 75 percent / 20percent NH4OH / methanol / 12 h / Ambient temperature 4: 40 percent / diethylaminosulfur trifluoride (DAST) / CH2Cl2 / 1 h / -65 - 20 °C View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
thionyl chloride
T=80°C; 72 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 148 ;
WO 2010/142801 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 7 h;
参考文献
Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234
反应条件
1: 76 percent / K2CO3 / dimethylformamide / 7 h / 20 °C
2: 56 percent / PPh3; CBr4 / CH2Cl2 / 0.5 h / -20 °C
View Scheme
参考文献
Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Kim, Dong Chan; Shin, Kye Jung; Paik, Young-Sook; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 231 - 234
