[(2R,3S,5R)-5-(2-氨基-6,8-二氧代-3,7-二氢嘌呤-9-基)-3-羟基四氢呋喃-2-基]甲基(羟基-膦酰氧基磷酰)磷酸氢酯合成路线 （共 2 条）
反应条件
(HNBu3)2P2O7; triethyl phosphite; trichlorophosphate in N,N-dimethyl-formamide Substitution;
参考文献
Nampalli, Satyam; Livshin, Inna; Kumar, Shiv
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 697 - 699
反应条件
1.1: Na / 3 h / 20 °C 1.2: 80 percent / dimethylsulfoxide / 16 h / 65 °C 2.1: POCl3; (EtO)3PO / 2 h / 0 - 5 °C 3.1: bis-tri-n-butylammonium pyrophosphate; nBu3N / dimethylformamide / 0.5 h / 20 °C 4.1: aq. TEAB / pH 7.2 View Scheme
参考文献
Nampalli, Satyam; Livshin, Inna; Kumar, Shiv
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 697 - 699
