1: With hydrogenchloride; hydrogen; palladium 10 on activated carbon in industrial methylated spirits T=20°C; 5.5 h; 2: With sodium hydrogencarbonate in dichloromethane

1: caesium carbonate; (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl / palladium diacetate / toluene / 20 h / 110 °C / Inert atmosphere 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 4 h / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 6.5 h / 20 °C 4: hydrogenchloride; hydrogen / palladium 10 on activated carbon / industrial methylated spirits / 5.5 h / 20 °C View Scheme

1: caesium carbonate; (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl / palladium diacetate / toluene / 20 h / 110 °C / Inert atmosphere 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 4 h / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 6.5 h / 20 °C 4: hydrogenchloride; hydrogen / palladium 10 on activated carbon / industrial methylated spirits / 5.5 h / 20 °C View Scheme

1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 4 h / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 6.5 h / 20 °C 3: hydrogenchloride; hydrogen / palladium 10 on activated carbon / industrial methylated spirits / 5.5 h / 20 °C View Scheme

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 6.5 h / 20 °C 2: hydrogenchloride; hydrogen / palladium 10 on activated carbon / industrial methylated spirits / 5.5 h / 20 °C View Scheme