1: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 2 h; 2: With sodium hydrogencarbonate in dichloromethane

1: N,N-dimethyl-formamide; water / 20 h / 20 °C / Inert atmosphere 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 7 h / 20 °C 3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C View Scheme

1: N,N-dimethyl-formamide; water / 20 h / 20 °C / Inert atmosphere 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 7 h / 20 °C 3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C View Scheme

1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 7 h / 20 °C 2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C View Scheme