1: With hydrogenchloride; water 6 h; Reflux; 2: With ammonium hydroxide in water

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '22847810', constants.ctx, '0')">Pd(OH)2/C (6 w/w)</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=20&deg;C;&nbsp;P=3800.26&nbsp;Torr;&nbsp;24&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 &deg;C / Inert atmosphere<br />1.2: 2 h / -78 &deg;C / Inert atmosphere<br />1.3: -78 - 20 &deg;C / Saturated solution<br />2.1: Pd(OH)2/C (6 w/w); hydrogen / methanol / 24 h / 20 &deg;C / 3800.26 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.25 h / 20 &deg;C / Inert atmosphere<br />1.2: 15 h / Inert atmosphere; Reflux<br />2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 &deg;C / Inert atmosphere<br />2.2: 2 h / -78 &deg;C / Inert atmosphere<br />2.3: -78 - 20 &deg;C / Saturated solution<br />3.1: Pd(OH)2/C (6 w/w); hydrogen / methanol / 24 h / 20 &deg;C / 3800.26 Torr<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.25 h / 20 &deg;C / Inert atmosphere<br />1.2: 15 h / Inert atmosphere; Reflux<br />2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 &deg;C / Inert atmosphere<br />2.2: 2 h / -78 &deg;C / Inert atmosphere<br />2.3: -78 - 20 &deg;C / Saturated solution<br />3.1: Pd(OH)2/C (6 w/w); hydrogen / methanol / 24 h / 20 &deg;C / 3800.26 Torr<br /> <br /> &nbsp;