2-[(3R,5R)-3,5-二[[(叔丁基)二甲基硅烷基]氧基]环己基亚基]乙醇合成路线 （共 2 条）
反应条件
1: [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol With n-butyllithium; p-toluenesulfonyl chloride in tetrahydrofuran; hexane
T=0°C; 3 h;
2: bis-diphenylphosphine With n-butyllithium in tetrahydrofuran
T=0°C; 2 h;
3: With dihydrogen peroxide in dichloromethane
T=22°C; 3.5 h;
参考文献
Hilpert, Hans; Wirz, Beat
Tetrahedron, 2001 , vol. 57, # 4 p. 681 - 694
反应条件
1: Me2S, NCS
2: H2O2
View Scheme
参考文献
CYTOCHROMA INC.; JOHNS HOPKINS UNIVERSITY; POSNER, Gary, H.; HESS, Lindsey, C.; KALINDA, Alvin, S.; SLACK, Rachel, D.; SAHA, Uttam; PETKOVICH, P., Martin
Patent: WO2011/88209 A2, 2011 ;
