1: methanol; caesium carbonate / 4 h / 20 °C 2: sodium periodate; ruthenium(III) chloride*(x)H2O / tetrachloromethane; water; acetonitrile / 8 h / 20 °C View Scheme

<b>Multi-step reaction with 7 steps<br /> </b>1.1: potassium <i>tert</i>-butylate / N,N-dimethyl-formamide / 0.5 h / 20 &deg;C<br />1.2: 18 h / 20 &deg;C / Cooling with ice<br />2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice<br />2.2: 2 h / 20 &deg;C<br />3.1: pyridine / dichloromethane / 15 h / 20 &deg;C<br />3.2: 6 h / 2 &deg;C<br />4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 &deg;C<br />5.1: pyridine / 6 h / 0 - 20 &deg;C<br />6.1: sodium tetrahydroborate / dimethyl sulfoxide / 3 h / 100 &deg;C<br />7.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 3.5 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1.1: potassium <i>tert</i>-butylate / N,N-dimethyl-formamide / 0.5 h / 20 &deg;C<br />1.2: 18 h / 20 &deg;C / Cooling with ice<br />2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice<br />2.2: 2 h / 20 &deg;C<br />3.1: pyridine / dichloromethane / 15 h / 20 &deg;C<br />3.2: 6 h / 2 &deg;C<br />4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 &deg;C<br />5.1: pyridine / 6 h / 0 - 20 &deg;C<br />6.1: sodium tetrahydroborate / dimethyl sulfoxide / 3 h / 100 &deg;C<br />7.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 3.5 h / 20 &deg;C<br /> <br /> &nbsp;