反应条件
1: 67 percent / phosphorus pentachloride / 0.5 h / 140 °C 2: 80 percent / CH3ONa / methanol / 4 h / 50 °C 3: 98 percent / H2 / 5percent Pd/C / tetrahydrofuran; methanol / 5 h / 760 Torr 4: 1.) aq. H2SO4, aq. NaNO2, 2.) H2O / 1.) 0 deg C, 0.5 h, 2.) 110 deg C, 0.5 h 5: 1.) NaH / 1.) THF, 2.) THF, 60 deg C, 1 h 6: 45 percent / boron tribromide / CH2Cl2 / 0.75 h / 0 - 20 °C View Scheme
参考文献
Hoffman; Smith; Rooney; Fisher; Wai; Thomas; Bamberger; Barnes; Williams; Jones; Olson; O'Brien; Goldman; Nunberg; Quintero; Schleif; Emini; Anderson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 8 p. 953 - 966
