1: With potassium tert-butylate in acetone T=0°C; 20 - 24 h; Zeolite of type 4A; 2: With lithium bromide in acetone Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: US2010/105898 A1, 2010 ;
Location in patent: Page/Page column 5-6 ;
1.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 24 h / 20 °C 1.2: 2 h / 20 °C 2.1: acetonitrile / 24 h / 20 °C 3.1: triethylamine; oxygen / acetonitrile / 48 h / 20 °C View Scheme