N-(3-羟基环己基)苯甲酰胺合成路线 （共 6 条）
反应条件
sodium hydroxide in water T=20°C; 3 h;
参考文献
Bernardelli, Patrick; Bladon, Michael; Lorthiois, Edwige; Manage, Ajith C.; Vergne, Fabrice; Wrigglesworth, Roger
Tetrahedron Asymmetry, 2004 , vol. 15, # 9 p. 1451 - 1455
反应条件
1: 80 percent / TMSOTf / diethyl ether; CCl4 / Ambient temperature 2: 93 percent / 16 h / Ambient temperature 3: aq. NaOH / 16 h / Ambient temperature 4: NaOH / 2.5 h View Scheme
参考文献
Johnson, A. Peter; Luke, Richard W. A.; Boa, Andrew N.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 9 p. 895 - 905
反应条件
1: 93 percent / 16 h / Ambient temperature 2: aq. NaOH / 16 h / Ambient temperature 3: NaOH / 2.5 h View Scheme
参考文献
Johnson, A. Peter; Luke, Richard W. A.; Boa, Andrew N.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 9 p. 895 - 905
参考文献
Burford et al.
Journal of the Chemical Society, 1957 , p. 2937,2940
反应条件
1.1: 75 percent / Et3N / tetrahydrofuran
2.1: Novozyme(R) 435 from Candida antarctica B / ethanol; toluene / 120 h / 18 - 22 °C
2.2: LiAlH4 / tetrahydrofuran / 72 h / Heating
2.3: H2 / Pd/C / ethanol / 16 h / 760 Torr
View Scheme
参考文献
Bernardelli, Patrick; Bladon, Michael; Lorthiois, Edwige; Manage, Ajith C.; Vergne, Fabrice; Wrigglesworth, Roger
Tetrahedron Asymmetry, 2004 , vol. 15, # 9 p. 1451 - 1455
反应条件
1.1: 75 percent / Et3N / tetrahydrofuran
2.1: Novozyme(R) 435 from Candida antarctica B / ethanol; toluene / 120 h / 18 - 22 °C
2.2: LiAlH4 / tetrahydrofuran / 72 h / Heating
2.3: H2 / Pd/C / ethanol / 16 h / 760 Torr
View Scheme
参考文献
Bernardelli, Patrick; Bladon, Michael; Lorthiois, Edwige; Manage, Ajith C.; Vergne, Fabrice; Wrigglesworth, Roger
Tetrahedron Asymmetry, 2004 , vol. 15, # 9 p. 1451 - 1455
