2-[[(2'-氰基[1,1'-联苯]-4-基)甲基][(1,1-二甲基乙氧基)羰基]氨基]-3-硝基苯甲酸甲酯合成路线 （共 12 条）
反应条件
potassium carbonate in acetonitrile 4 h; Heating;
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
potassium carbonate in acetonitrile T=82°C; 5 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1420016 A1, 2004 ;
Location in patent: Page 16-17 ;
反应条件
1: SOCl2, DMF / toluene / 0.5 h / Heating 2: NaN3 / acetone; H2O / 1 h 3: 1.5 h / Heating 4: 85 percent / K2CO3 / acetonitrile / 4 h / Heating View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: NaN3 / acetone; H2O / 1 h 2: 1.5 h / Heating 3: 85 percent / K2CO3 / acetonitrile / 4 h / Heating View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: concd. H2SO4 / methanol 2: SOCl2, DMF / toluene / 0.5 h / Heating 3: NaN3 / acetone; H2O / 1 h 4: 1.5 h / Heating 5: 85 percent / K2CO3 / acetonitrile / 4 h / Heating View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: 1.5 h / Heating 2: 85 percent / K2CO3 / acetonitrile / 4 h / Heating View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 2: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 3: 78 percent / ethanol / 1.5 h / Heating View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 2: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 3: 91 percent / acetic acid / 0.67 h / 80 - 90 °C 4: 100 percent / trimethyltin azide / toluene / 29 h / Heating 5: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
hydrogenchloride in ethyl acetate 1 h; Ambient temperature;
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
反应条件
1: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature 2: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h 3: 91 percent / acetic acid / 0.67 h / 80 - 90 °C View Scheme
参考文献
Kubo, Keiji; Kohara, Yasuhisa; Imamiya, Eiko; Sugiura, Yoshihiro; Inada, Yoshiyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2182 - 2195
