2-乙氧基-1-[[(2'-腈基连苯-4-取代)甲基]苯并咪唑]-7-羧酸乙酯合成路线 （共 5 条）
反应条件
1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C 2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C 3: sodium hydroxide; water / 3 h / 50 °C 4: potassium carbonate; p-toluenesulfonyl chloride; 4-(N,N-dimethlyamino)pyridine / N,N-dimethyl acetamide / 3 h / 30 °C View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
反应条件
sodium hydroxide in methanol; toluene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5196444 A1, 1993 ;
US 5196444 A
反应条件
azido-tri-n-butylstannane in o-xylene T=25 - 35°C; Heating / reflux;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2008/44244 A2, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C 2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C 3: sodium hydroxide; water / 3 h / 50 °C View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
反应条件
1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C 2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C View Scheme
参考文献
Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana
Organic Process Research and Development, 2013 , vol. 17, # 1 p. 77 - 86
