2-乙氧基-1-[[(2’-(1H-四唑-5-基)联苯-4-基)甲基]苯并咪唑]-7-甲酸乙酯合成路线 （共 13 条）
反应条件
1: With sodium hydroxide; water in methanol T=78 - 80°C; 1 h; 2: With acetic acid in ethyl acetate T=10 - 15°C; pH=4 - 5;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/51929 A1, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
1.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 1.2: 3 h / 0 °C / pH 4 2.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Dasari; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2011/145100 A1, 2011 ;
反应条件
1.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux 1.2: 3 h / 0 °C / pH 4 2.1: triethylamine / dichloromethane / 8 h / 0 - 20 °C 3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 2 h / 75 °C 4.1: hydrogen / palladium 10 on activated carbon / toluene; methanol / 20 °C / 2280.15 Torr View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Dasari; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2011/145100 A1, 2011 ;
