caesium carbonate; 1,4-di(diphenylphosphino)-butane; palladium diacetate in ethylene glycol dimethyl ether; water T=50°C; 24 h;

1.1: HF / H2O / 1 h / 20 °C 1.2: 97 percent / H2O / 1 h / 20 °C 2.1: 60 percent / dppb; Cs2CO3 / Pd(OAc)2 / 1,2-dimethoxy-ethane; H2O / 24 h / 50 °C View Scheme