2-(7-甲氧基萘-1-基)乙胺盐酸盐合成路线 （共 35 条）
反应条件
1.1: potassium carbonate / methanol / 28 °C 1.2: 2.4 h / 15 - 25 °C 1.3: 2 h / 25 - 90 °C 2.1: hydrogenchloride / methanol; water / 4 h / 30 - 70 °C View Scheme
反应条件
1.1: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 3.1: ammonia / toluene / 0 - 5 °C / pH 10 - 11 4.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C 5.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr 5.2: 1 h / 50 - 55 °C View Scheme
反应条件
1.1: potassium hydroxide / tert-butyl alcohol / 2 h / 85 - 90 °C 2.1: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 3.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 4.1: ammonia / toluene / 0 - 5 °C / pH 10 - 11 5.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C 6.1: sodium hydroxide; hydrogen / water; methanol; isopropyl alcohol / 25 - 30 °C / 7500.75 Torr 6.2: 1 h / 50 - 55 °C View Scheme
反应条件
sodium acetate in ethanol Heating / reflux;
参考文献
Souvie, Jean-Claude; Gonzalez Blanco, Isaac; Thominot, Gilles; Chapuis, Genevieve; Horvath, Stephane; Damien, Gerard
Patent: US2005/182276 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
potassium carbonate in chloroform; water 0.5 h; Ambient temperature;
参考文献
Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239
反应条件
potassium carbonate in water pH=9; 2 h;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; ANNA REDDY, Ambati
Patent: WO2012/127483 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
potassium carbonate in chloroform; water 0.5 h; Ambient temperature;
参考文献
Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239
反应条件
potassium carbonate in chloroform; water 0.5 h; Ambient temperature;
参考文献
Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239
反应条件
1: 2-(7-methoxynaphthalen-1-yl)ethylamine hydrochloride With potassium carbonate in water; ethyl acetate T=20°C; Schotten-Baumann reaction; 2: 2-bromo acetyl bromide in water; ethyl acetate T=0 - 20°C; Schotten-Baumann reaction; 1 h;
参考文献
Ettaoussi, Mohamed; Sabaouni, Ahmed; Rami, Marouan; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Spedding, Michael; Caignard, Daniel-Henri; Berthelot, Pascal; Yous, Said
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 310 - 323
反应条件
potassium carbonate in chloroform; water 0.5 h; Ambient temperature;
参考文献
Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239
