sodium; acetic acid in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate

hydrogen; sodium acetate; palladium on activated charcoal in water; acetonitrile P=2585.7 Torr; 0.5 h;

1: 96 percent / acetonitrile / 1 h / Heating 2: 5.2 g / phosphorous oxychloride / 24 h / 90 °C 3: 85 percent / Cl2 / acetonitrile; H2O 4: 95 percent / methanol / 0.5 h 5: 3.75 g / sodium acetate hydrate, hydrogen / 10percent Pd/C / acetonitrile; H2O / 0.5 h / 2585.7 Torr View Scheme

1: 5.2 g / phosphorous oxychloride / 24 h / 90 °C 2: 85 percent / Cl2 / acetonitrile; H2O 3: 95 percent / methanol / 0.5 h 4: 3.75 g / sodium acetate hydrate, hydrogen / 10percent Pd/C / acetonitrile; H2O / 0.5 h / 2585.7 Torr View Scheme

1: 85 percent / Cl2 / acetonitrile; H2O 2: 95 percent / methanol / 0.5 h 3: 3.75 g / sodium acetate hydrate, hydrogen / 10percent Pd/C / acetonitrile; H2O / 0.5 h / 2585.7 Torr View Scheme

1: 95 percent / methanol / 0.5 h 2: 3.75 g / sodium acetate hydrate, hydrogen / 10percent Pd/C / acetonitrile; H2O / 0.5 h / 2585.7 Torr View Scheme