苯基甲基N-[(2S)-4-氨基-1-[[(2S,3S)-4-[(2S)-2-(叔丁基氨基甲酰)吡咯烷-1-基]-3-羟基-4-氧代-1-苯基丁烷-2-基]氨基]-1,4-二氧代丁烷-2-基]氨基甲酸酯合成路线 （共 12 条）
反应条件
1.1: 1-hydroxybenzotriazol; N-ethyl-N'-[3-(dimethylamino)propyl]carbodiimide*HCl / CH2Cl2 / 0.5 h 1.2: 93 percent / CH2Cl2 2.1: HCl / dioxane; CH2Cl2 / 2 h 3.1: 1-hydroxybenzotriazol; N-ethyl-N'-[3-(dimethylamino)propyl]carbodiimide*HCl; TEA / dimethylformamide 4.1: HCl / dioxane; CH2Cl2 / 2 h 5.1: 86 percent / 1-hydroxybenzotriazol; TEA / dimethylformamide View Scheme
参考文献
Mimoto; Imai; Tanaka; Hattori; Kisanuki; Akaji; Kiso
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 3088 - 3088
反应条件
diethyl cyanophosphonate; triethylamine in N,N-dimethyl-formamide 16 h; Ambient temperature; Yield given;
参考文献
Asagarasu, Akira; Uchiyama, Taketo; Achiwa, Kazuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 697 - 703
