4-(咪唑并[1,2-a]吡啶-2-基)苯胺合成路线 （共 5 条）
反应条件
hydrogen; Raney-nickel in ethanol; ethyl acetate T=20°C; P=2585.81 Torr;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; HAMILTON, Bradford, S.; MACK, Juergen; REDEMANN, Norbert; SCHOELCH, Corinna
Patent: WO2011/48018 A1, 2011 ;
Location in patent: Page/Page column 41-42 ;
WO 2011/048018 A1
反应条件
hydrogen; 5 palladium over charcoal in tetrahydrofuran; methanol 5 h;
参考文献
EP1612204 A1, ;
Page/Page column 33 ;
反应条件
1: 86 percent / sodium carbonate / acetonitrile / 6 h / Heating 2: 78 percent / sodium sulfide nonahydrate / H2O / 48 h / 90 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 72, # 6 p. 1327 - 1334
反应条件
1: 2)HBr / 1) acetone, reflux, 3 h, 2) methanol, reflux, 60 min 2: H2 / Raney Ni / ethanol / 760 Torr View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 1 p. 129 - 137
反应条件
1: acetone / 3 h / Heating; Reflux 2: hydrogen / Raney-nickel / ethyl acetate; ethanol / 20 °C / 2585.81 Torr View Scheme
参考文献
WO2011/48018 A1, ;
WO 2011/048018 A1
