1-甲基-3-丙基-1H-吡唑-5-甲酸合成路线 （共 12 条）
反应条件
1: With sodium hydroxide; water T=80°C; 2 h; 2: With hydrogenchloride; water
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/194529 A1, 2008 ;
Location in patent: Page/Page column 56-57 ;
US 20080194529 A1
反应条件
1: in dichloromethane Heating; 2: With sodium hydroxide in water 4 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 5 p. 1045 - 1050
反应条件
1: N2H2 2: NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
2: NaOH / H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 15 p. 1819 - 1824
反应条件
1.1: 70 percent / NaOEt / ethanol / 0 - 20 °C 2.1: CH2Cl2 / Heating 2.2: 54 percent / 5 percent aq. sodium hydroxide / H2O / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 5 p. 1045 - 1050
反应条件
1.1: nitric acid; sulfuric acid / 10 h / 50 - 55 °C / |Large scale 2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 6 h / 50 - 60 °C 2.2: 1.67 h / 20 °C 3.1: hydrogen; 5 palladium on charcoal / ethyl acetate / 4 h / 50 °C / 2585.81 Torr 4.1: ethyl acetate / 70 h / 20 °C View Scheme
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
反应条件
1: HNO3; H2SO4 2: NH3 View Scheme
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
反应条件
1: HNO3; H2SO4 2: NH3 3: SnCl2 4: NEt3; DMAP / CH2Cl2 View Scheme
参考文献
Haning, Helmut; Niewoehner, Ulrich; Schenke, Thomas; Lampe, Thomas; Hillisch, Alexander; Bischoff, Erwin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3900 - 3907
反应条件
1: HNO3; H2SO4 2: NH3 3: SnCl2 4: NEt3; DMAP / CH2Cl2 5: NaOH / ethanol View Scheme
参考文献
Haning, Helmut; Niewoehner, Ulrich; Schenke, Thomas; Lampe, Thomas; Hillisch, Alexander; Bischoff, Erwin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3900 - 3907
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
