1-甲基-4-硝基-3-丙基-1H-吡唑-5-羧酸合成路线 （共 9 条）
反应条件
sulfuric acid; nitric acid T=80°C; 4 h;
参考文献
Kopp; Lancelot; Dallemagne; Rault
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1045 - 1050
反应条件
1: N2H2 2: NaOH 3: HNO3; H2SO4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1.1: 70 percent / NaOEt / ethanol / 0 - 20 °C 2.1: CH2Cl2 / Heating 2.2: 54 percent / 5 percent aq. sodium hydroxide / H2O / 4 h / Heating 3.1: 100 percent / sulfuric acid; nitric acid / 4 h / 80 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 5 p. 1045 - 1050
反应条件
1: NaOH 2: HNO3; H2SO4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 6 h / 50 - 60 °C 1.2: 1.67 h / 20 °C 2.1: hydrogen; 5 palladium on charcoal / ethyl acetate / 4 h / 50 °C / 2585.81 Torr 3.1: ethyl acetate / 70 h / 20 °C View Scheme
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
反应条件
1: With thionyl chloride in N,N-dimethyl-formamide; toluene T=50 - 60°C; 6 h; 2: With ammonia in N,N-dimethyl-formamide; toluene T=20°C; 1.66667 h;
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
反应条件
1: NH3 2: SnCl2 3: NEt3; DMAP / CH2Cl2 View Scheme
参考文献
Haning, Helmut; Niewoehner, Ulrich; Schenke, Thomas; Lampe, Thomas; Hillisch, Alexander; Bischoff, Erwin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3900 - 3907
反应条件
1: NH3 2: SnCl2 3: NEt3; DMAP / CH2Cl2 4: NaOH / ethanol View Scheme
参考文献
Haning, Helmut; Niewoehner, Ulrich; Schenke, Thomas; Lampe, Thomas; Hillisch, Alexander; Bischoff, Erwin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3900 - 3907
反应条件
1: NH3 2: SnCl2 View Scheme
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
