1-甲基-4-硝基-3-丙基-(1H)-吡唑-5-甲酰胺合成路线 （共 9 条）
反应条件
1: With thionyl chloride in N,N-dimethyl-formamide; toluene T=50 - 60°C; 6 h; 2: With ammonia in N,N-dimethyl-formamide; toluene T=20°C; 1.66667 h;
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
反应条件
1: HNO3; H2SO4 2: NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1: N2H2 2: NaOH 3: HNO3; H2SO4 4: NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1: NaOH 2: HNO3; H2SO4 3: NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1: hydrogen; 5 palladium on charcoal / ethyl acetate / 4 h / 50 °C / 2585.81 Torr 2: ethyl acetate / 70 h / 20 °C View Scheme
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
反应条件
1: SnCl2 2: NEt3; DMAP / CH2Cl2 View Scheme
参考文献
Haning, Helmut; Niewoehner, Ulrich; Schenke, Thomas; Lampe, Thomas; Hillisch, Alexander; Bischoff, Erwin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3900 - 3907
反应条件
1: SnCl2 2: NEt3; DMAP / CH2Cl2 3: NaOH / ethanol View Scheme
参考文献
Haning, Helmut; Niewoehner, Ulrich; Schenke, Thomas; Lampe, Thomas; Hillisch, Alexander; Bischoff, Erwin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3900 - 3907
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate T=50°C; P=3040.2 Torr;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/194529 A1, 2008 ;
Location in patent: Page/Page column 57 ;
US 20080194529 A1
反应条件
hydrazine hydrate in water
参考文献
Orchid Chemicals and Pharmaceuticals Ltd.
Patent: EP1077214 A1, 2001 ;
