4-氨基-1-甲基-3-正丙基-1H-吡唑-5-羧酰胺合成路线 （共 22 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate T=50°C; P=3040.2 Torr;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/194529 A1, 2008 ;
Location in patent: Page/Page column 57 ;
US 20080194529 A1
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 15 p. 1819 - 1824
反应条件
1: NH3 2: SnCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1: 90 percent / MnO2 2: 90 percent / polymer-supported BEMP / ethanol 3: NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 17 p. 1983 - 1986
反应条件
1: N2H2 2: NaOH 3: HNO3; H2SO4 4: NH3 5: SnCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
1: NaOH 2: HNO3; H2SO4 3: NH3 4: SnCl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907
反应条件
ammonia ammonolysis; transesterification;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 17 p. 1983 - 1986
反应条件
acetic acid T=50°C; 1 h;
参考文献
Maruthikumar; Rao, P. Hanumantha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 2 p. 343 - 345
反应条件
1: diethyl sulphate; 2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)benzoic acid in N,N-dimethyl-formamide T=60°C; Alkylation; 2: With HOBt-6-carboxamidomethyl polystyrene; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in N,N-dimethyl-formamide Condensation; 3: 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide With isocyanate resin in tetrahydrofuran Acylation;
参考文献
Baxendale, Ian R.; Ley, Steven V.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1983 - 1986
反应条件
in ethyl acetate T=20°C; 70 h;
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
