4-氨基-1-甲基-3-正丙基-1H-吡唑-5-羧酰胺合成路线 （共 22 条）
反应条件
1: Et3N, DMAP / CH2Cl2 2: NaOH / ethanol; H2O 3: 1) ClSO3H / 1), 2) EtOH View Scheme
参考文献
Terrett, Nicholas K.; Bell, Andrew S.; Brown, David; Ellis, Peter
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1819 - 1824
反应条件
triethylamine in ethyl acetate T=0 - 25°C; 2 h; Product distribution / selectivity;
参考文献
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
Patent: WO2008/74512 A1, 2008 ;
Location in patent: Page/Page column 18; 14 ;
反应条件
in anhydrous xylene; ethyl acetate
参考文献
Dunn, Peter James; Dunne, Catherine
Patent: US2002/13464 A1, 2002 ;
反应条件
1.1: dimethylformamide / 60 °C 1.2: polymer-supported HOBt; PyBrOP / dimethylformamide 1.3: isocyanate resin / tetrahydrofuran 2.1: 100 percent / NaOEt / ethanol / 0.17 h / 120 °C / microwave irradiation View Scheme
参考文献
Kumar, Indukuri V.S.; Ramanjaneyulu, Gorantla S.; Bindu, Vurimindi H.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 668 - 673
反应条件
1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane 2: sodium hydroxide / diethylene glycol 3: potassium carbonate / acetone / Reflux View Scheme
参考文献
Kumar, Indukuri V.S.; Ramanjaneyulu, Gorantla S.; Bindu, Vurimindi H.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 668 - 673
反应条件
1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane 2: sodium hydroxide / diethylene glycol 3: potassium carbonate; potassium iodide / acetone / 4 h / 20 °C / Inert atmosphere; Reflux View Scheme
参考文献
Kumar, Indukuri V.S.; Ramanjaneyulu, Gorantla S.; Bindu, Vurimindi H.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 668 - 673
反应条件
in N,N-dimethyl-formamide pH=7.4; aq. phosphate bufferHeating;
参考文献
Park, Hee-Moon; Chang, Bong-Jun; Jin, Hangkyo; Kim, Jeong-Hoon
Asian Journal of Chemistry, 2012 , vol. 24, # 9 p. 4163 - 4165
反应条件
copper chloride in ethanol T=70°C; 0.5 h;
参考文献
Abdel-Jalil, Raid J.; Khanfar, Monther; Al-Gharabli, Samer; El-Abadelah, Mustafa M.; Eichele, Klaus; Anwar, Muhammad Usman; Voelter, Wolfgang
Heterocycles, 2005 , vol. 65, # 8 p. 1821 - 1827
反应条件
1: NEt3; DMAP / CH2Cl2 2: NaOH / ethanol View Scheme
参考文献
Terrett, Nicholas K.; Bell, Andrew S.; Brown, David; Ellis, Peter
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1819 - 1824
反应条件
acetic acid T=50°C; 1 h;
参考文献
Maruthikumar; Rao, P. Hanumantha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 2 p. 343 - 345
