1.1: triethylamine; potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / |Large scale 2.1: sodium hydroxide / methanol / 4 h / |Reflux; |Large scale 3.1: 1,1'-carbonyldiimidazole / methanol / 1 h / 20 °C / |Reflux; |Large scale 3.2: 0.5 h / |Large scale View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11343078', constants.ctx, '0')">sodium tetrahydroborate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '742035', constants.ctx, '0')">trifluoroacetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=15 - 20&deg;C;&nbsp;6&nbsp;h;&nbsp;&nbsp;Large scale;&nbsp;<br /> &nbsp;