4-乙酰基-5-羰基己酸甲酯合成路线 （共 19 条）
反应条件
1: acetylacetone With sodium in ethanol T=0°C; 0.166667 h; 2: acrylic acid methyl ester in ethanol T=0 - 20°C; 1.16667 h; Heating / reflux; 3: With acetic acid in ethanol
参考文献
SANOFI PASTEUR SA
Patent: US2008/242857 A1, 2008 ;
Location in patent: Page/Page column 14-15 ;
反应条件
potassium tert-butylate in tert-butyl alcohol 20 h; Ambient temperature;
参考文献
Ceccherelli, Paolo; Curini, Massimo; Marcotullio, Maria Carla; Rosati, Ornelio; Wenkert, Ernest
Journal of Organic Chemistry, 1994 , vol. 59, # 10 p. 2882 - 2884
反应条件
potassium fluoride in methanol T=65°C; Addition;
参考文献
Brower, Justin O.; Lightner, David A.; McDonagh, Antony F.
Tetrahedron, 2000 , vol. 56, # 40 p. 7869 - 7883
反应条件
carbon dioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=25°C; Michael Addition; 2 h;
参考文献
Peeters, Annelies; Ameloot, Rob; De Vos, Dirk E.
Green Chemistry, 2013 , vol. 15, # 6 p. 1550 - 1557
反应条件
1: acetylacetone With potassium carbonate in N,N-dimethyl-formamide T=55°C; 0.333333 h; 2: methyl 3-bromo-propionate in N,N-dimethyl-formamide T=55°C; 18 h; Overall yield = 30 percent; Overall yield = 600 mg;
参考文献
Rackham, Mark D.; Brannigan, James A.; Rangachari, Kaveri; Meister, Stephan; Wilkinson, Anthony J.; Holder, Anthony A.; Leatherbarrow, Robin J.; Tate, Edward W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2773 - 2788
参考文献
March
Annales de Chimie (Cachan, France), 1902 , vol. <7> 26, p. 305
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1901 , vol. 132, p. 697
参考文献
Goldschmidt,S.; Beer,L.
Justus Liebigs Annalen der Chemie, 1961 , vol. 641, p. 40 - 50
反应条件
1: 91 percent / hydroxylamine hydrochloride / H2O; methanol / 12 h / Heating 2: 83 percent / KOH / methanol / 3 h / Heating View Scheme
参考文献
Ceccherelli, Paolo; Curini, Massimo; Marcotullio, Maria Carla; Rosati, Ornelio; Wenkert, Ernest
Journal of Organic Chemistry, 1994 , vol. 59, # 10 p. 2882 - 2884
反应条件
ethanol; sodium ethanolate anschliessend mit Methyljodid;
参考文献
Baumgarten; Eifert
Journal of Organic Chemistry, 1953 , vol. 18, p. 1177,1179
反应条件
potassium hydroxide in methanol Heating;
参考文献
Bulletin de la Societe Chimique de France, , p. 823 - 827
