4-乙酰基-5-羰基己酸甲酯合成路线 （共 19 条）
反应条件
1: hydroxylamine hydrochloride / water; methanol / 18 h / |Reflux 2: lithium hydroxide hydrate / methanol / 18 h / 20 °C View Scheme
参考文献
Rackham, Mark D.; Brannigan, James A.; Rangachari, Kaveri; Meister, Stephan; Wilkinson, Anthony J.; Holder, Anthony A.; Leatherbarrow, Robin J.; Tate, Edward W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2773 - 2788
反应条件
acetic acid; zinc T=65°C;
参考文献
Pereira, Nelson; Serra, Armenio C.; Pineiro, Marta; Gonsalves, Antonio M. D'A. Rocha; Abrantes, Margarida; Laranjo, Mafalda; Botelho, Filomena
Journal of Porphyrins and Phthalocyanines, 2010 , vol. 14, # 5 p. 438 - 445
反应条件
acetic acid
3.5 h; Heating / reflux;
参考文献
SANOFI PASTEUR SA
Patent: US2008/242857 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
acetic acid
Heating;
参考文献
Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5598 - 5604
反应条件
acetic acid; zinc
T=50°C; 11 h;
参考文献
Cheng, Lingjiang; Lightner, David A.
Synthesis, 1999 , # 1 p. 46 - 48
反应条件
acetic acid; zinc
1 h; Heating;
参考文献
Berezin, M. V.; Semeikin, A. S.; V'yugin, A. I.; Krestov, G. A.
Russian Chemical Bulletin, 1993 , vol. 42, # 3 p. 449 - 453
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1993 , # 3 p. 495 - 499
反应条件
acetic acid; zinc
T=80°C; 4 h;
参考文献
Cheng, Lingjiang; Lightner, David A.
Synthesis, 1999 , # 1 p. 46 - 48
反应条件
sodium acetate; acetic acid; zinc in water
T=65°C; 2 h;
参考文献
Smith, Kevin M.; Pandey, Ravindra K.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1383 - 1388
反应条件
1: acetoacetic acid tert-butyl ester With acetic acid; sodium nitrite
T=5°C;
2: 3-(2-methoxycarbonyl-ethyl)-2,4-pentanedione With sodium acetate; acetic acid; zinc
T=65°C;
参考文献
Schmuck, Carsten; Rupprecht, Daniel; Urban, Christian; Walden, Nicholas
Synthesis, 2006 , # 1 art. no. T05905SS, p. 89 - 96
