2-乙基-1,3-二硝基-苯合成路线 （共 8 条）
反应条件
1: With sulfuric acid; acetic acid; sodium nitrite in water T=20 - 25°C; 1 h; 2: With copper(I) oxide in ethanol; water T=20°C; 1.5 h;
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
sulfuric acid; nitric acid
参考文献
Hansch; Helmkamp
Journal of the American Chemical Society, 1951 , vol. 73, p. 3080
反应条件
1.1: 48 percent / ammonia; H2S / dioxane / 35 - 40 °C 2.1: NaNO2; AcOH; H2SO4 / H2O / 1 h / 20 - 25 °C 2.2: 76 percent / Cu2O / ethanol; H2O / 1.5 h / 20 °C View Scheme
参考文献
Brady; Day; Allam
Journal of the Chemical Society, 1928 , p. 981
反应条件
1: 96 percent / HNO3; H2SO4 2: 24 percent / Cu-bronze / quinoline / Heating View Scheme
参考文献
Nikolaides, Nick; Bogdan, Sophie E.; Szalma, James S.
Synthetic Communications, 2002 , vol. 32, # 13 p. 2027 - 2033
参考文献
Brady; Day; Allam
Journal of the Chemical Society, 1928 , p. 981
参考文献
Brady; Day; Allam
Journal of the Chemical Society, 1928 , p. 981
反应条件
1.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
2.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
2.2: urea / H2O / 0.08 h
2.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
3.1: 2 percent / NaCN / dimethylsulfoxide / 2 h / 20 °C
View Scheme
参考文献
Buehler, Sigrid; Lagoja, Irene; Giegrich, Heiner; Stengele, Klaus-Peter; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2004 , vol. 87, # 3 p. 620 - 659
反应条件
1.1: 81 percent / formic acid; Et3N / Pd/C / acetonitrile / 0.42 h / Heating
2.1: aq. HBr; NaNO2 / H2O / 0.17 h / 0 °C
2.2: urea / H2O / 0.08 h
2.3: 87 percent / CuSO4*5H2O; Cu; aq. HBr / H2O / 1 h / 80 °C
View Scheme
参考文献
Uyeo
Nippon Kagaku Kaishi, 1942 , vol. 63, p. 1452,1455
Chem.Abstr., 1947 , p. 3066
