in Sec-butyl alcohol T=20 - 102°C; 21 h; Reagent/catalystTemperatureTimeSolventConcentration;

1: With trichlorophosphate T=20 - 85°C; 2: With potassium carbonate in water pH=9 - 10; Product distribution / selectivity;

1.1: potassium tert-butylate / butan-1-ol / 4 h / 60 - 93 °C 2.1: trichlorophosphate / 20 - 85 °C 2.2: pH 9 - 10 View Scheme

1: hydrogenchloride / water / 5 h / 100 °C 2: sodium hydroxide / water; acetone / 3.08 h / 0 - 40 °C View Scheme

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 4-(N,N-dimethlyamino)pyridine / 1-methyl-pyrrolidin-2-one / 0.5 h 1.2: 4.5 h / 20 - 85 °C 2.1: N-bromosuccinmide; ammonium acetate / dichloromethane / 4 h 2.2: pH 10 - 11 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 20 °C 3.2: 24.5 h / 100 - 110 °C 4.1: sodium hydroxide; water / isopropyl alcohol / 5.5 h / 20 - 75 °C View Scheme