(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵合成路线 （共 6 条）
139893-43-9(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵
→
反应条件
in xylenes T=138 - 140°C; 0.5 h;
参考文献
US2004/19225 A1, ;
Page 3 ;
139893-43-9(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵
→
反应条件
in toluene T=100°C; 6 h;
参考文献
Askin, D.; Verhoeven, T. R.; Liu, T. M.-H.; Shinkai, I.
Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4929 - 4932
139893-43-9(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵
→
反应条件
in xylenes T=138 - 140°C; 0.5 h;
参考文献
Dandala, Ramesh; Sebastian, Sonny; Reddy, Sanapureddy Jagan Mohan; Sivakumaran, Meenakshisunderam
Patent: US2004/19225 A1, 2004 ;
Location in patent: Page 3 ;
139893-43-9(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵+
→
参考文献
Ranbaxy Laboratories Limited
Patent: US5939564 A1, 1999 ;
反应条件
acetic acid; trifluoroacetic acid in water
参考文献
Merck and Co., Inc.
Patent: US4916239 A1, 1990 ;
139893-43-9(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵
→
反应条件
hydrogenchloride in water; ethyl acetate pH=~ 4.0; 0.5 h; Product distribution / selectivity;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2005/239885 A1, 2005 ;
Location in patent: Page/Page column 13 ;
