反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1.1: sodium hydroxide / water / 25 °C<br />1.2: 10 - 15 °C / pH 2 - 3<br />2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 5 °C<br />3.1: 4-(N,N-dimethlyamino)pyridine; pyridine / dichloromethane / 4 h / 5 - 20 °C<br />4.1: ethyl acetate; methanol / 1 h / 30 - 75 °C<br /> <br />
参考文献
JUBILANT LIFE SCIENCES LIMITED; BISWAS,. Sujay; DUBEY, Shailendra Kumar; BANSAL, Vikas; MASAND, Mukesh; VIR, Dharam Patent: WO2012/120356 A2, 2012 ;
