1.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / pentane / 16 h / 0 - 21 °C
2.1: C36H44FeP2; copper(I) bromide dimethylsulfide complex / diethyl ether; tert-butyl methyl ether / 0.25 h / -78 °C
2.2: 16 h / -78 °C
3.1: diisobutylaluminium hydride / dichloromethane / 2 h / -50 °C
View Scheme
参考文献
Mulder, Monique P. C.; Fodran, Peter; Kemmink, Johan; Breukink, Eefjan J.; Kruijtzer, John A. W.; Minnaard, Adriaan J.; Liskamp, Rob M. J.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 37 p. 7491 - 7502
1: 72 percent / toluene / 20 h / Heating
2: 43 percent / PPA / 6 h / 110 °C
3: 80 percent / NaBH4 / methanol / 3 h / 20 °C
4: 71 percent / Et3SiH-BF3-OEt2 / CH2Cl2 / 15 h / 50 °C
View Scheme
参考文献
van Oeveren, Arjan; Pio, Barbara A.; Tegley, Christopher M.; Higuchi, Robert I.; Wu, Min; Jones, Todd K.; Marschke, Keith B.; Negro-Vilar, Andres; Zhi, Lin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1523 - 1526
