1-苄氧基-3-氯-2-丙醇合成路线 （共 23 条）
反应条件
tin(IV) chloride in dichloromethane
T=-50 - -20°C; Cyclization; 1 h;
参考文献
Sugita, Yoshiaki; Kimura, Yoko; Yokoe, Ichiro
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5877 - 5880
反应条件
1: With chloro-trimethyl-silane; 1,2-ferrocenediyl(-PPh2=C(COPh)-N=C(Me)-) in dichloromethane
T=20°C; 3 h;
2: With hydrogenchloride in diethyl ether
T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Paek, Seung Hwan; Shim, Sang Chul; Cho, Chan Sik; Kim, Tae-Jeong
Synlett, 2003 , # 6 p. 849 - 851
反应条件
tin(IV) chloride in dichloromethane
T=-50 - -20°C; Cyclization; 1 h;
参考文献
Sugita, Yoshiaki; Kimura, Yoko; Yokoe, Ichiro
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5877 - 5880
反应条件
sodium azide; diethylaluminium chloride in toluene
1 h, -78 deg C then 16 h, 25 deg C;
参考文献
Benedetti, Fabio; Berti, Federico; Norbedo, Stefano
Tetrahedron Letters, 1998 , vol. 39, # 43 p. 7971 - 7974
反应条件
tin(IV) chloride in dichloromethane
T=-50 - -20°C; Cyclization; 1 h;
参考文献
Sugita, Yoshiaki; Kimura, Yoko; Yokoe, Ichiro
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5877 - 5880
反应条件
Montmorillonite K 10 in tetrachloromethane
2.5 h; Heating;
参考文献
Thuy, Vu Moc; Petit, Huguette; Maitte, Pierre
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 3 p. 261 - 262
反应条件
1: 90 percent / tetrabutylammonium hydrogen sulfate, 50percent aq. NaOH / 24 h / 0 °C
2: 81 percent / Li2CuCl4 / tetrahydrofuran / 24 h
View Scheme
参考文献
Lundhaug, Kamilla; Overbeeke, P.L. Antoine; Jongejan, Jaap A.; Anthonsen, Thorleif
Tetrahedron Asymmetry, 1998 , vol. 9, # 16 p. 2851 - 2856
反应条件
di(n-butyl)tin oxide; cesium fluoride
1) toluene, 15 min, reflux, 2) DMF, r.t., 22 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nagashima; Ohno
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 8 p. 1972 - 1982
反应条件
1: 92 percent / 50percent aq. NaOH / 1 h / 5 °C
2: 90 percent / 72percent HClO4 / H2O / 80 °C
3: 36 percent / NaH / tetrahydrofuran / 24 h / Heating
View Scheme
参考文献
Nakatsuji, Yohji; Nakamura, Tetsuya; Okahara, Mitsuo; Dishong, Dennis M.; Gokel, George W.
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1237 - 1242
反应条件
1: satd. aq. NaOH / 10 h / Ambient temperature
2: 72 percent HClO4 / H2O / 12 h / 80 °C
3: 1.) Li-tert-butoxid, 2.) LiBr*H2O / 1.) tert-Butanol, reflux, 2.) reflux, ca. 12 d
View Scheme
参考文献
Gloe, K.; Muehl, P.; Beger, J.; Poeschmann, C.; Petrich, M.; Beyer, L.
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 3 p. 413 - 421
