citric acid in water; ethyl acetate 0.25 h; Inert atmosphere; Product distribution / selectivity;

sodium tert-pentoxide in 2-methyl cyclohexane; toluene T=20 - 45°C; 1.5 h;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 38 - 40 &deg;C<br />1.2: 0 - 25 &deg;C<br />2.1: ethyl acetate / 18 h / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: sodium hydrogencarbonate / toluene; water; methanol / 1 h / 20 - 25 &deg;C<br />1.2: -15 - 26 &deg;C<br />2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 38 - 40 &deg;C<br />2.2: 0 - 25 &deg;C<br />3.1: ethyl acetate / 18 h / 0 - 20 &deg;C<br /> <br /> &nbsp;