1,3-二甲基-6-(甲基氨基)-5-硝基尿嘧啶合成路线 （共 4 条）
反应条件
in dichloromethane; chloroform; water T=20°C; 1 h; Inert atmosphere;
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
Location in patent: Page/Page column 44 ;
WO 2011/114184 A1
反应条件
1: trichlorophosphate / water / 3 h / Reflux 2: nitric acid / sulfuric acid / 2 h / 10 °C 3: dichloromethane; chloroform; water / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
1: nitric acid / sulfuric acid / 2 h / 10 °C 2: dichloromethane; chloroform; water / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
1: hydrogen / palladium 10 on activated carbon / methanol / 20 °C
2: tetrahydrofuran / 18 h / 20 °C / Inert atmosphere; Reflux
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
