4-溴-2-甲基苯-1-磺酰氯合成路线 （共 5 条）
反应条件
chlorosulfonic acid in chloroform T=0°C; 4 h;
参考文献
Chen, Qiao-Hong; Rao, P. N. Praveen; Knaus, Edward E.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2459 - 2468
反应条件
chlorine; acetic acid
参考文献
Journal of the American Chemical Society, , vol. 73, p. 3013,3016
反应条件
ammonium hydroxide in 1,4-dioxane T=0°C; 6 h;
参考文献
Gao, Rui; Liao, Sha; Zhang, Chen; Zhu, Weilong; Wang, Liyan; Huang, Jin; Zhao, Zhenjiang; Li, Honglin; Qian, Xuhong; Xu, Yufang
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 597 - 604
反应条件
1: 4-bromo-2-methyl-benzene-sulfonyl chloride With sodium hydrogencarbonate; sodium sulfite in water
T=75°C; 1.16667 h;
2: monobromoacetic acid in water
T=105°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOFFMANN, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KLICIC, Jasna; SCHAENZLE, Gerhard; WOLLIN, Stefan Ludwig Michael; CONVERS-REIGNIER, Serge Gaston; EAST, Stephen Peter; MARLIN, Frederic Jacques; McCARTHY, Clive; SCOTT, John
Patent: US2013/29949 A1, 2013 ;
Location in patent: Paragraph 0181; 0182; 0183 ;
反应条件
aluminium trichloride
参考文献
Truce; Amos
Journal of the American Chemical Society, 1951 , vol. 73, p. 3013,3016
