反应条件
1.1: sulfuric acid / 120 - 125 °C 2.1: potassium carbonate; sodium iodide / acetone / Reflux 3.1: sodium tetrahydroborate / ethylene glycol dimethyl ether / 0.17 h 3.2: 3 h / 10 °C 4.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C 5.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube 6.1: isopropyl alcohol / 15 h / 25 - 86 °C 7.1: sodium hydroxide / water 8.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux 8.2: 1 h / -65 - -60 °C 9.1: thionyl chloride / 10 °C / Reflux 10.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 25 - 30 °C 11.1: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 50 - 55 °C View Scheme
参考文献
ALEMBIC PHARMACEUTICALS LIMITED; RAMAN, Jayaraman, Venkat; PATEL, Samir; THAKOR, Indrajit; LADANI, Mahesh; PATIL, Chetan; PATEL, Ronak; RAVAL, Prashant; PAREKH, Viral; SHAH, Hiral
Patent: WO2012/137047 A1, 2012 ;
