2-甲基-5-乙烯基吡啶合成路线 （共 24 条）
反应条件
caesium carbonate; triphenylphosphine in water T=75 - 80°C; 19 h; Inert atmosphere;
参考文献
US2011/152248 A1, ;
Page/Page column 42 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; N,N-dimethyl-formamide T=20 - 100°C; Inert atmosphere;
参考文献
MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco
Patent: WO2010/51503 A1, 2010 ;
Location in patent: Page/Page column 249 ;
WO 2010/051503 A1
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 2: 6-Methyl-3-pyridine-carboxaldehyde in tetrahydrofuran; hexane T=0 - 20°C;
参考文献
WO2009/110985 A2, ;
Page/Page column 63 ;
WO 2009/110985 A2
反应条件
chromium corundum T=600°C;
反应条件
1.1: n-butyl-magnesium chloride; methyllithium / tetrahydrofuran / 0.5 h / -10 - 0 °C 1.2: 1 h 1.3: 1 h / 40 °C 2.1: thionyl chloride; sodium hydroxide / isopropanol acetate 2.2: 4 h / 50 °C View Scheme
反应条件
ammonia; water; oxygen; vanadium pentoxide; Titanium(IV) oxide T=380°C; Product distribution; Further Variations:reaction times;
参考文献
Russian Journal of Applied Chemistry, , vol. 75, # 7 p. 1104 - 1107
反应条件
potassium phosphate in isobutyramide T=100°C; 24 h; Inert atmosphere;
参考文献
MEDIVATION NEUROLOGY, INC.
Patent: WO2009/111540 A1, 2009 ;
Location in patent: Page/Page column 27 ;
反应条件
1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere 1.2: 1 h / Inert atmosphere 2.1: phosphorus tribromide / diethyl ether / 3 h / 0 °C / Inert atmosphere 3.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 4.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme
参考文献
MEDIVATION NEUROLOGY, INC.
Patent: WO2009/111540 A1, 2009 ;
反应条件
potassium permanganate in water T=80°C; 0.05 h;
参考文献
Suvorov, B. V.; Bakirova, S. B.; Serazetdinova, V. A.; Ishaeva, D. T.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 11/12 p. 894 - 896
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 11-12 p. 81 - 83
反应条件
sodium periodate; osmium(VIII) oxide in ethylene glycol dimethyl ether; water
参考文献
Ludwig Heumann and Co. GmbH
Patent: US4559344 A1, 1985 ;
US 4559344 A
