2-氨基-5-二乙基氨基戊烷合成路线 (共 57 条)
反应条件
supported Candida antartica lipase B in tert-butyl methyl ether
T=38 - 40°C; 6 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286
参考文献
I.G. Farbenind.
Patent: DE683692 , 1937 ;
DRP/DRBP Org.Chem.
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Winthrop Chem. Co.
Patent: US2233970 , 1938 ;
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Price; Roberts
Journal of the American Chemical Society, 1946 , vol. 68, p. 1204,1206
Organic Syntheses, 1955 , vol. Coll. Vol. III, p. 272
反应条件
T=100 - 155°C; 5.5 h;
参考文献
Cheng, Jianjun; Zeidan, Ryan; Mishra, Swaroop; Liu, Aijie; Pun, Suzie H.; Kulkarni, Rajan P.; Jensen, Gregory S.; Bellocq, Nathalie C.; Davis, Mark E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6522 - 6531
反应条件
a) 80-100 deg C, 1 h, b) 135-150 deg C, 8 h;
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
1: 5-(3-fluoroanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione in diphenylether
T=300°C; 0.0833333 h; microwave irradiation;
2: With trichlorophosphate
3 h; Heating;
3: 2-amino-5-(diethylamino)pentane T=135 - 155°C; 2 h; Title compound not separated from byproducts;
参考文献
Madrid, Peter B.; Sherrill, John; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1015 - 1018
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
反应条件
a) 80-100 deg C, 1 h, b) 135-150 deg C, 8 h;
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
sodium iodide; phenol
T=170°C;
参考文献
Steck et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1012,1014
参考文献
Knunjanz et al.
Izv. Akad. S.S.S.R. Otd. Chim. estestv., 1934 , p. 153,163
Chem. Zentralbl., 1935 , vol. 106, # I p. 1896
参考文献
Riegel et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1229,1231