4-甲基-2-甲硫基嘧啶合成路线 （共 28 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=20°C;
参考文献
Collis, Alan J; Foster, Martyn L; Halley, Frank; Maslen, Christopher; McLay, Iain M; Page, Kenneth M; Redford; Souness, John E; Wilsher, Nicola E
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 693 - 696
反应条件
1: 4-methyl-2-methylsulphanylpyrimidine With sodium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.5 h; 2: 4-Fluorobenzoic acid methyl ester in tetrahydrofuran T=20°C; 3 h; Further stages.;
参考文献
McKenna, Jeffrey M.; Halley, Frank; Souness, John E.; McLay, Iain M.; Pickett, Stephen D.; Collis, Alan J.; Page, Kenneth; Ahmed, Imtiaz
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2173 - 2184
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Griffin, John; Lanza, Guido; Yu, Jessen
Patent: US2005/261354 A1, 2005 ;
Location in patent: Page/Page column 96; 97 ;
US 20050261354 A1
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=0 - 20°C; 1.66667 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/76441 A1, 2003 ;
Location in patent: Page/Page column 80-81 ;
反应条件
1: 30percent aq. H2O2, HCOOH / Ambient temperature 2: 79 percent / ethanol / 1.) ice bath, 2.) room temperature View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
phosgene 1.) toluen, chloroform, 35 deg C, 40 min, 2.) toluen, chloroform, a.) 40 deg C, 18 h, b.) RT, 1h; Yield given. Multistep reaction;
参考文献
Brown, Desmond J.; Cowden, William B.; Grigg, Geoffrey W.; Kavulak, Diana
Australian Journal of Chemistry, 1980 , vol. 33, # 10 p. 2291 - 2298
反应条件
lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethyl acetate
参考文献
Nantermet, Philippe G.; Selnick, Harold G.; Barrow, James C.; Coburn, Craig; Burgey, Christopher; Robinson, Kyle A.; Lyle, Terry Alan
Patent: US2003/158218 A1, 2003 ;
US 20030158218 A1
参考文献
Matsukawa; Yoshida
Yakugaku Zasshi, 1949 , vol. 69, p. 27,29
Chem.Abstr., 1950 , p. 3453
反应条件
1: 4-methyl-2-methylsulphanylpyrimidine With lithium diisopropyl amide in tetrahydrofuran; hexane T=-80 - -5°C; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-80°C; Reflux; 3: With hydrogenchloride in tetrahydrofuran; hexane; water
参考文献
Susnik, Marko P.; Schnuerch, Michael; Mihovilovic, Marko D.; Mereiter, Kurt; Stanetty, Peter
Monatshefte fur Chemie, 2009 , vol. 140, # 4 p. 423 - 430
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
参考文献
Rupert, Kenneth C.; Henry, James R.; Dodd, John H.; Wadsworth, Scott A.; Cavender, Druie E.; Olini, Gilbert C.; Fahmy, Bohumila; Siekierka, John J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 347 - 350
