1: 96 percent / NaOMe / methanol; CH2Cl2 / 4.5 h 2: 1.) molecular sieves 4A, 2.) mercury(II) bromide / 1.) CH2Cl2, 15 min, 2.) CH2Cl2, room temperature, 24 h 3: 53 percent / pyridine / 8 h / Ambient temperature 4: 86 percent / hydrogen, acetic acid / palladium-carbon / ethanol / 2 h / Ambient temperature 5: 1.) molecular sieves 4A, 2.) trimethylsilyl triflate / 1.) CH2Cl2, room temperature, 30 min, 2.) CH2Cl2, room temperature, 45 min 6: 84 percent / sodium methoxide / methanol / 48 h / Heating View Scheme

1: 53 percent / pyridine / 8 h / Ambient temperature 2: 86 percent / hydrogen, acetic acid / palladium-carbon / ethanol / 2 h / Ambient temperature 3: 1.) molecular sieves 4A, 2.) trimethylsilyl triflate / 1.) CH2Cl2, room temperature, 30 min, 2.) CH2Cl2, room temperature, 45 min 4: 84 percent / sodium methoxide / methanol / 48 h / Heating View Scheme

1: 86 percent / hydrogen, acetic acid / palladium-carbon / ethanol / 2 h / Ambient temperature 2: 1.) molecular sieves 4A, 2.) trimethylsilyl triflate / 1.) CH2Cl2, room temperature, 30 min, 2.) CH2Cl2, room temperature, 45 min 3: 84 percent / sodium methoxide / methanol / 48 h / Heating View Scheme

1: 1.) molecular sieves 4A, 2.) trimethylsilyl triflate / 1.) CH2Cl2, room temperature, 30 min, 2.) CH2Cl2, room temperature, 45 min 2: 84 percent / sodium methoxide / methanol / 48 h / Heating View Scheme