2-氨基-3-(5-叔丁基-3-氧代-1,2-恶唑-4-基)丙酸合成路线 （共 6 条）
反应条件
hydrogen bromide T=140°C; 0.25 h;
参考文献
Lauridsen, Joern; Honore, Tage; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 668 - 672
反应条件
1: 1.) sodium ethoxide / 1.) ethanol, RT, 2 h, 2.) ethanol, 60 deg C, 3 h 2: 75 percent / aq. hydroxylammonium chloride, NaOH / 1.67 h / -5 °C 3: 24.2 percent / diethyl ether / 2 h 4: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 1.33 h / Heating 5: ethanol / 5 h / Heating 6: 77 percent / 48percent aq. hydrobromic acid / 0.25 h / 140 °C View Scheme
参考文献
Lauridsen, Joern; Honore, Tage; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 668 - 672
反应条件
1: 58 percent / SOCl2 / 0.42 h / Heating 2: 62 percent / NaH / dimethylformamide / 6 h / 100 °C 3: 41 percent / aq. HBr / 0.42 h / 140 °C View Scheme
参考文献
Johansen, Tommy N.; Hawes, Calvin R.; Ellis, Gareth J.; Ebert, Bjarke; Stensbol, Tine B.; Da Graca Thrige, Dorthe; Krogsgaard-Larsen, Povl
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 937 - 947
反应条件
1: 62 percent / NaH / dimethylformamide / 6 h / 100 °C 2: 41 percent / aq. HBr / 0.42 h / 140 °C View Scheme
参考文献
Johansen, Tommy N.; Hawes, Calvin R.; Ellis, Gareth J.; Ebert, Bjarke; Stensbol, Tine B.; Da Graca Thrige, Dorthe; Krogsgaard-Larsen, Povl
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 937 - 947
反应条件
1: CH2Cl2 / 2 h 2: 69 percent / dimethylformamide / 14 h / Ambient temperature 3: 30 percent / trifluoroacetic acid / 14 h / Heating View Scheme
参考文献
Slok; Ebert; Lang; Krogsgaard-Larsen; Lenz; Madsen
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 4 p. 329 - 338
反应条件
1: 69 percent / dimethylformamide / 14 h / Ambient temperature 2: 30 percent / trifluoroacetic acid / 14 h / Heating View Scheme
参考文献
Slok; Ebert; Lang; Krogsgaard-Larsen; Lenz; Madsen
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 4 p. 329 - 338
