反应条件
1: triphenylphosphine, Br2 / toluene / 20 h / 23 °C
2: CH3SO3H / 3 h / 23 °C
3: Ac2O, TEA / dimethylformamide / 1 h
4: HCl / H2O
5: Pb(OAc)4 / CH2Cl2 / 3 h / Heating
6: 12.9 g / 3N HCl / acetone; H2O / 1 h / Heating
7: 1.) LDA / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 to -65 deg C
8: 2.7 g / KOH / ethanol / 4 h / 23 °C
View Scheme
参考文献
Lipinski, Christopher A.; Aldinger, Charles E.; Beyer, Thomas A.; Bordner, Jon; Burdi, Douglas F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2169 - 2177
