2-氯-4,6-二甲基吡啶-3-胺合成路线 （共 4 条）
反应条件
sodium hydroxide; bromine 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min;
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: 97 percent / POCl3 / 3 h / Heating 2: 100 percent / conc. H2SO4 / 2 h / 120 °C 3: 75 percent / Br2, aq. NaOH / 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: 100 percent / conc. H2SO4 / 2 h / 120 °C 2: 75 percent / Br2, aq. NaOH / 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
phosphorus tribromide 48 h; Heating / reflux;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2004/78728 A1, 2004 ;
Location in patent: Page 16; 17 ;
WO 2004/078728 A1
