2-氯-4,6-二甲基烟酰胺合成路线 （共 5 条）
反应条件
sulfuric acid T=120°C; 2 h;
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: 97 percent / POCl3 / 3 h / Heating 2: 100 percent / conc. H2SO4 / 2 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1887 - 1897
反应条件
hydrazine hydrate; N,N-dimethyl-formamide in ethanol 5 h; Heating;
参考文献
Kalme, Z. A.; Roloff, B.; Pelcher, Yu. E.; Popelis, Yu. Yu.; Khagen, F.; Dubur, G. Ya
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 9 p. 1031 - 1035
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 9 p. 1218 - 1222
反应条件
sulfuric acid; sodium nitrite
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
sodium hydroxide; bromine 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min;
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
