[Rh(acac)2(CO)2]; N-(3-diphenylphosphanylbenzoyl)guanidine; hydrogen in dichloromethane T=40°C; P=11251.1 Torr; 29 h; Autoclave; chemoselective reaction;

triethylamine in tetrahydrofuran; dichloromethane

triethylamine in dichloromethane 12 h;

pyridine 1.) 0 deg C to r.t., 2.) r.t., overnight;

1: 57.8 percent / CrO3, 3.5 M aq. H2SO4 / acetone / 1.) 0 deg C to r.t., 2.) r.t., 1.5 h 2: 93.6 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / 2 h 3: 66.6 percent / sodium methoxide / methanol / Ambient temperature View Scheme