1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran
T=-10 - 20°C; 2 h;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
T=0 - 40°C; 1 h;
3: With hydrogen; palladium-on-charcoal in methanol
12 h;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; CHOI, Soo Jin; LEE, Byung Goo; OH, Seong Soo; KIM, Yong Tae; EO, Jin Yong; KIM, Hung Sop
Patent: WO2012/148246 A2, 2012 ;
Location in patent: Page/Page column 15; 16 ;